CD8A and neoplasm: In addition to abovementioned EAE model (19, 36, 37), CD8+CD122hiLy49+ Tregs have documented functions in various settings, including colitis (38, 39), hepatitis (40), arthritis (41), diabetes (42, 43), viral infection (44), tumor immunity (45), atherogenesis (46) and organ transplantation (47).