Among distinct pSS subgroups, the number of CXCL13-positive cells per tissue area was significantly higher in pSS patients with severe MSG infiltrates (median, range: 5.59, 0.46-11.14) compared to those with mild lesions (0.0, 0.0-0.0, p=0.0025) or SSL (0.00, 0.00-3.63, p=0.021) (Figures 1B, C), as well as in pSS patients at high risk to develop lymphoma compared to those at low risk (4.18, 0.28-8.54 and 0.00, 0.00-11.14, respectively; p=0.016). This evidence concerns the gene CXCL13 and peeling skin syndrome.