Although the BLM treatment did not changed the ratio of phosphorylated (p)-STING to total STING, expression of STING, p-STING, p-TBK1, and p-IRF3 in lung tissue was clearly elevated, suggesting that BLM treatment activates the cGAS-STING pathway (Figure 4C). The gene discussed is IRF3; the disease is Bloom syndrome.