Yet, in late sepsis there was downregulation of other cytotoxic lymphocyte genes KLRC3 and KLRC1. Interestingly, late sepsis activated CD4+ T-lymphocytes also demonstrated upregulation of some cytotoxic genes such as GZMA, CCL5, and CST7 (40, 42, 43). This evidence concerns the gene CST7 and Sepsis.