For example, PLAU is shared between CRD (rs2227551, rs2227564), MS (rs2688608), and PSO (rs2675662); ITGAM is shared between GRD (rs57348955), PSO (rs12445568, rs10782001, rs13708) and SLE (rs11150610); RAP1A is shared between CRD (rs488200) and PSO (rs11121129); and ATP8B4 is targeted by the pleiotropic SNPs rs12946510, rs12946510, rs12946510 - associated with CRD, MS, and ULC; rs2305480, rs2305480 -associated with RA and ULC; and non-pleiotropic SNPs- rs883770 (SSC), and rs2290400 (TID). This evidence concerns the gene PLAU and myeloid sarcoma.