Ten distinct ANA patterns implicated in the SLE diagnosis were observed in our cohort of SLE patients where most of the cases displayed a nuclear large/coarse speckled pattern (AC-5; n = 19/45; 42.2%), followed by nuclear homogeneous (AC-1; n = 7/45; 15.6%), nuclear fine speckled (AC-4; n = 7/45; 15.6%), smooth nuclear envelope (AC-11; n = 5/45; 11.1%), homogeneous nucleolar (AC-8; n = 2/45; 4.4%), and one case each (2.2%) for nuclear dense fine speckled (AC-2), centromere (AC-3), PCNA-like (AC-13), cytoplasmic dense fine speckled (AC-19), and NuMA-like (AC-26). The gene discussed is ASAH1; the disease is systemic lupus erythematosus.