Corresponding to the genetics analysis of EA patient, we conjectured that the loss-of-function mutation of FLG probably results in the reduction of the adhesion molecule E-cadherin and the secretion of type 2 cytokines (TSLP and IL-33) in bronchial epithelial cells which may result in the on-set or exacerbation of asthma. The gene discussed is FLG; the disease is Esophageal atresia.