Besides, SPINK5 rs2303063 G>A allele was linked to early-onset allergic EA (P=0.011, OR 6.344 comparing GA and GG genotype), and TLR4 rs75048248 C>T allele was associated with frequent-exacerbation EA (P = 0.018, OR 10.154 comparing CT and CC genotype). The gene discussed is SPINK5; the disease is Esophageal atresia.