Later protocols using transplanted Eμ-Myc fetal liver cells (typically HSCs and HSPCs) yielded B cell lymphomas that could be accelerated by loss of tumor suppressors in the germline (e.g. Trp53, Cdkn2a, p19ARF) and by retroviral expression of cooperating ORFs (125, 135, 157, 162). The gene discussed is MYC; the disease is neoplasm.