Sequencing samples from 17 mice confirmed mutation of human DLBCL drivers including Pim1, Myc, Kmt2d, Nfkbia, Stat3, Pou2f2, and Hist1h1e. In a similar study, conditional expression in germinal center B cells of Myc and constitutively activated Akt (fusing p85 to p110) gave rise to Burkitt’s lymphoma (BL) like disease with recurrent mutations in Ccnd3, which is mutated in BL and known to regulate germinal center B cell proliferation (49). This evidence concerns the gene PIM1 and Burkitt lymphoma.