In an early study a series of Trp53 shRNAs introduced into Eμ-Myc HSCs were found to accelerate lymphomagenesis in a manner that correlated with the strength of knockdown (155) and similar results were obtained for the mir-17–19b microRNA (160) and for shRNAs against Puma (Bbc3, a proapoptotic downstream target of Trp53) (156) and Bcor (a tumor suppressor of Burkitt lymphoma) (54). This evidence concerns the gene BBC3 and neoplasm.