CD8A and type 1 diabetes mellitus: Recently, it has been reported that β cell peptides including insulin B chain, GAD and Islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP) are prone to bind HLA-A2 in T1D patients and autoreactive CD8+ T cell response to many HLA-A*0201–restricted β cell peptides (34).