Genome-wide association studies have identified variants in 11 genomic regions (loci) as risk factors for PCOS; however, only INSR, FSHR, and LHCHR, which encode receptors for insulin, FSH, and LH/hCG, respectively, have clear functional relevance to the pathophysiology of PCOS (25, 26). This evidence concerns the gene PLOD1 and polycystic ovary syndrome.