According to Han et al., H19 could control the expression of cell-cycle regulatory genes including cyclin D1, cyclin E1, and Cyclin Dependent Kinase 4 (CDK4) by combining with the Eukaryotic Translation Initiation Factor 4A3 (eIF4A3) and hampering the recruitment of eIF4A3 to their transcripts, thus accelerating cell-cycle progression and CRC proliferation (105). The gene discussed is CDK4; the disease is colorectal carcinoma.