PTTG1 and pituitary gland adenoma: Furthermore, miR-338-3p overexpression reduced GHR mRNA levels as well as the expression of other genes involved in the pathogenesis of pituitary adenomas (62); however, no direct miRNA- mRNA target interactions have been proved so far, therefore further investigations are needed to clarify the role of this promising miRNA in pituitary tumorigenesis particularly concerning its relationship with Pttg1.