Specifically, miR-34b, miR-326, miR-432, miR-548c-3p, miR-570, and miR-603, were found to be down-regulated in GH secreting adenomas leading to increased mRNA and protein levels of their target genes including High Mobility Group AT-Hook 1 (HMGA1), High Mobility Group AT-Hook 2 (HMGA2), and E2F Transcription Factor 1 (E2F1) (52). The gene discussed is E2F1; the disease is adenoma.