In a more recent study, we reported the association between these brain measures, including reduced MCP and SCP width, midbrain, and area of the pons cross-sectional area with increased expression levels of the Iso10/10b, Iso4/4b FMR1 mRNA isoforms of the ASFMR1 131 bp mRNA isoform (17), suggesting their potential role in the pathogenesis of FXTAS. Here, FMR1 is linked to fragile X-associated tremor/ataxia syndrome.