Besides, studies have also shown that irisin facilitates glucose uptake by skeletal muscles, increases insulin sensitivity of tissues, stimulates mitochondrial biogenesis and oxidative metabolism, improving the metabolic profile (Boström et al., 2012; Rodríguez et al., 2017) and attenuates the expression of obesity-related inflammatory markers (Lu and Li, 2020; Luo et al., 2020). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.