During sepsis, LPS/LTA can activate the MAPK signaling pathway, and further accelerate the production of proinflammatory cytokines, such as IL-1β, IL-6, and TNF-α, which form the cytokine cascade, and eventually leads to cell apoptosis and multiple organ dysfunction (Zhang et al., 2015; Wang et al., 2020). This evidence concerns the gene IL6 and Sepsis.