NEDD4 and Sepsis: In summary, these results indicate that ST interacts with and ubiquitinates caspase-11 through Nedd4, thereby inhibiting LPS-induced caspase-11 activation in hepatocytes, ultimately leading to caspase-11-mediated pyroptosis inhibition in hepatocytes, which is manifested by the reduction of liver damage and improvement of the general condition during sepsis.