Furthermore, USP5 is also found to contribute to the tumorigenesis and progression of many malignancies, including neuroblastoma (Cheung et al., 2021), hepatocellular carcinoma (Liu et al., 2017b; Meng et al., 2019), multiple myeloma (Mollaoglu et al., 2017; Wu et al., 2020), pancreatic carcinoma (Kaistha et al., 2017; Li et al., 2017; Lian et al., 2020), ovarian cancer (Kim et al., 2018; Du et al., 2019), colorectal cancer (Xu et al., 2019), and non-small cell lung cancer (Ma et al., 2018; Xue et al., 2020). This evidence concerns the gene USP5 and exocrine pancreatic carcinoma.