Previous studies had reported that USP1, USP8, USP11, and USP28 were indispensable for GBM growth via increasing the protein stability of ID1, FLIPS, PML, and c-Myc, respectively (Lee et al., 2010; Panner et al., 2010; Guo et al., 2013; Wu et al., 2014). Here, USP8 is linked to glioblastoma.