In addition, the frequent necrosis in tumor cells leads to DNA damage and nuclear rupture, and the persistent presence of DNA in the cytoplasm will lead to the chronic activation of cGAS-STING, which has the opposite effect, resulting in the activation of STING-dependent non-normative NF-κB pathway (Reislander et al., 2019). The gene discussed is STING1; the disease is neoplasm.