The rest of the genes associated with CPVT usually affect normal calcium channels by acting on the RYR2 and CQSA2 proteins, which will change the structure of the normal proteins that control the transfer of Ca2+ in cardiomyocytes, resulting in abnormal Ca2+ concentrations causing arrhythmias. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.