In addition to the above-mentioned related sites, several studies have shown that mutations at multiple sites on the RyR2 gene can lead to CPVT in different altered ways, including G203C, V4653F, S2246L, N4104K, and P2328S (Priori and Chen, 2011; Venetucci et al., 2012; Leinonen et al., 2018). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.