Song et al. (2019) revealed that ivermectin induced glioma cells apoptosis by upregulating the expressions of p53 and Bax, downregulating Bcl-2, activating cleaved caspase-3, and cleaved caspase-9. Zhang et al. (2019) observed that the ratio of Bax/Bcl-2 in the cytoplasm increased in ivermectin-induced apoptosis of Hela cells. This evidence concerns the gene CASP3 and central nervous system cancer.