Recently, accumulated studies have suggested that the mtDNA-cGAS -STING pathway proved critical to the progression of cardiovascular diseases (Mao et al., 2017; Cao et al., 2018; Sliter et al., 2018; Li et al., 2019; Hu et al., 2020; Huang et al., 2020; Zhang et al., 2020). This evidence concerns the gene STING1 and cardiovascular disorder.