Besides, we have demonstrated that Gal3, which is strongly upregulated in DAM (Krasemann et al., 2017); (Mathys et al., 2017), exerts a noxious role under different brain disease conditions including AD (Boza-Serrano et al., 2019), brain ischaemia (Burguillos et al., 2015) and traumatic brain injury (Yip et al., 2017). The gene discussed is LGALS3; the disease is Alzheimer disease.