We have also shown that Gal3 plays a role in α-synuclein-induced microglial activation (Burguillos et al., 2015); (Boza-Serrano et al., 2014) and that Gal3 regulates inflammatory response in Alzheimer’s disease (Boza-Serrano et al., 2019). Here, LGALS3 is linked to early-onset autosomal dominant Alzheimer disease.