PTEN and familial pancreatic carcinoma: NF-κB, miR-221, COX-2, and their effectors such as PTEN, p27, p57, and pro-inflammatory cytokines. STAT-1, STAT-3 phosphorylation, and Notch signaling pathway. Pancreatic cancer cell lines (MiaPaCa-2, Panc-1, AsPC-1, BxPC-3, and Pan02)