APOE*3-Leiden.CETP mice are more suitable than wild-type mice as a preclinical model to study the effects of different treatments on plasma lipid levels and inflammatory conditions, such as atherosclerosis and non-alcoholic steatohepatitis (Ason et al., 2014; Kühnast et al., 2015a; Kühnast et al., 2015b; Pouwer et al., 2020; van den Hoek et al., 2020; van den Hoek et al., 2014; Westerterp et al., 2006). Here, APOE is linked to alcoholic fatty liver disease.