ACSL1 and Sepsis: To validate the reliable expression changes of the sepsis-associated lncRNAs participated in trans-regulation detected in GSE63311 RNA-seq data, the three DElncRNAs (CTB-61M7.2, RP11-284N8.3, and LINC00861) and three highly co-expressed DEmRNAs (ACSL1, CD2, and IL7R) in the co-expression network (Figure 2C) were further selected for qRT-PCR validation using the blood samples collected from 19 normal controls and 23 patients with sepsis.