Besides exerting a role in the pathogenesis to fatty liver disease, obesity, atherosclerosis, diabetes, neurological disorders, and specific types of cancer (Yan et al., 2015), ACSL1 palys a likely role in driving inflammasome-mediated release of pro-inflammatory factors by neutrophils during sepsis, based on both profiling of the literature (Al-Rashed et al., 2019; Kalugotla et al., 2019; Roelands et al., 2019) and transcript co-expression analysis (Cheng et al., 2016). Here, ACSL1 is linked to obesity due to melanocortin 4 receptor deficiency.