While APP/KI and APP/PS1 mouse models of amyloidosis have been tested in the IntelliCage, to date, the 3xTg-AD model has not been evaluated in this automated behavioral phenotyping apparatus (Ryan et al., 2013; Lee et al., 2015; Masuda et al., 2016; Mifflin et al., 2021). Here, APP is linked to Alzheimer disease.