MAPT and Alzheimer disease: Key neuropathological features of AD include extracellular plaques of the amyloid-β (Aβ) peptide, neurofibrillary tangles (NFTs)—intraneuronal tangles of hyperphosphorylated tau–and synaptic and neural loss (Honjo et al., 2012; Bakota and Brandt, 2016; Lane et al., 2018).