It is worth noting that pathologic tau and Aβ accumulation in the cholinergic nucleus basalis emerged early in AD (Arendt et al., 1988; Mesulam et al., 2004), and volume reductions in the basal forebrain were observed in patients with AD (Kilimann et al., 2014) and individuals with SCD (Scheef et al., 2019). Here, MAPT is linked to Alzheimer disease.