MAPT and Parkinson disease: For instance, the Aβ/Tau/neurodegeneration in AD-related disease (Jack et al., 2016), the “Hot cross bun” in multiple system atrophy with cerebellar ataxia (Zhu et al., 2021), and the motor abnormalities and α-synuclein in Parkinson’s disease (PD) (Xie et al., 2019) have been proven to be potential biomarkers for an early detection of these diseases.