Collectively, the pathology of Aβ/tau/neurodegeneration in regions of the DMN, hippocampus, and basal forebrain has been investigated but much remains to be learned about the variations in coordination with other regions in normal controls (NCs) and those in SCD, amnestic mild cognitive impairment (aMCI), and AD. The gene discussed is MAPT; the disease is Schnyder corneal dystrophy.