CP and amyotrophic lateral sclerosis: AMPAR-mediated excitotoxicity, attributed to Ca2+ influx through CP-AMPARs, is implicated in the selective motor neuron loss and thus the development of ALS (Rothstein et al., 1990, 1993; Carriedo et al., 1995; Ikonomidou et al., 1996; Bar-Peled et al., 1999; Tateno et al., 2004; Hideyama et al., 2010; Yamashita and Kwak, 2014, 2019; Selvaraj et al., 2018).