CP and neurodegenerative disease: Fourth, CP-AMPARs increase in neurodegenerative disease models (Whitehead et al., 2017), but NMDARs decrease, although in a few cases they may also increase, during neural degeneration (Malinow, 2012; Avila et al., 2017; Foster et al., 2017; Wang and Reddy, 2017; Liu J. et al., 2019), strongly suggesting more persistent effects of excitotoxicity from CP-AMPARs.