Whereas the role of NF-κB and the proteasome under stroke conditions has already been shown (Ridder and Schwaninger, 2009; Harari and Liao, 2010; Doeppner et al., 2013; Lv et al., 2019), the mutual interaction between MMP-9 and ABCB1 on the one hand and NF-κB on the other hand has just recently been described by us in a murine stroke model (Zhang et al., 2021). The gene discussed is MMP9; the disease is stroke disorder.