CD274 and neoplasm: Furthermore, in a pattern similar to MS, these GAAs also demonstrate intratumoral regional specificity with those within the tumor core resembling progenitors, whereas those localized to the tumor periphery exhibiting a mature, anti-inflammatory astrocytic profile characterized by CD274+, glial fibrillary acidic protein (GFAP+) and upregulation of A2 associated genes (Zhang et al., 2016; Henrik Heiland et al., 2019).