Microglia within the area of tumor necrosis exhibit the highest expression of markers associated with antibody-dependent cell-mediated cytotoxicity, whereas those localized to the tumor periphery exhibit increased expression of molecules suggestive of phagocytic capacity, such as complement CR3 (Morimura et al., 1990; Badie and Schartner, 2001; Li and Graeber, 2012). Here, CRIPTO3 is linked to neoplasm.