Despite their theoretical capability of inducing strong anti-tumor T-cell responses and priming CD4+ and CD8+ T-cells against tumor antigens, pDC infiltration is found to be associated with poor prognosis in several solid tumors (Hartmann et al., 2003; Salio et al., 2003; Conrad et al., 2012; Sawant et al., 2012). This evidence concerns the gene CD8A and neoplasm.