STAT3-activated GAAs promote tumor progression by contributing to the immunosuppressive microenvironment through the secretion of pro-tumor cytokines, upregulation of programmed death ligand-1 (PD-L1/CD274), reprogramming of microglia toward an anti-inflammatory (M2) phenotype, and facilitating glioma cell adaption to exploit the hypoxic conditions of the surrounding TME (Malo et al., 2018; Brandao et al., 2019; Henrik Heiland et al., 2019). This evidence concerns the gene CD274 and central nervous system cancer.