AQP4 and ischemic stroke: This pathophysiological process is in line with evidence demonstrating that AQP4-deficient mice and wild types treated with AQP4 inhibitors progress with less cerebral edema after ischemic stroke (Manley et al., 2000; Igarashi et al., 2011; Yao et al., 2015; Hirt et al., 2017; Pirici et al., 2018).