However, the lymphocytes in the CLNs involved in the immune damage of stroke also include T and B cells, and many factors, such as neuropilin-2 (Xu et al., 2010), angiopoietins (Alitalo, 2006), BMP9-ALK1 (Yoshimatsu et al., 2013), DAMPs (Shichita et al., 2017), may participate in the activation of lymphatic endothelium after stroke. This evidence concerns the gene GDF2 and stroke disorder.