Moreover, GCD formation has been shown to be accompanied by a loss of Reelin-producing neurons in the hippocampus of MTLE patients (Haas et al., 2002; Liu et al., 2020) and in rodent epilepsy models (Heinrich et al., 2006; Gong et al., 2007; Antonucci et al., 2008; Duveau et al., 2011; Orcinha et al., 2016). The gene discussed is RELN; the disease is epilepsy.