Many types of CMT have shown to have cytoskeletal abnormalities (Brownlees et al., 2002), including mutations in PMP22 (CMT1A), MFN2 (CMT2A2), RAB7 (CMT2B), GARS1 (CMT2D), NEFL (CMT2E), HSPB1 (CMT2F), FIG4 (CMT4J), FGD4 (CMT4H), DNM2 (DI-CMT), and GJB1 (CMT1X). This evidence concerns the gene RAB7A and Charcot-Marie-Tooth disease.