Many types of CMT have shown to have cytoskeletal abnormalities (Brownlees et al., 2002), including mutations in PMP22 (CMT1A), MFN2 (CMT2A2), RAB7 (CMT2B), GARS1 (CMT2D), NEFL (CMT2E), HSPB1 (CMT2F), FIG4 (CMT4J), FGD4 (CMT4H), DNM2 (DI-CMT), and GJB1 (CMT1X). The gene discussed is DNM2; the disease is Charcot-Marie-Tooth disease.