While genetic mutations leading to CMT also affect other cellular processes (e.g., genes coding for human aminoacyl tRNA synthetases such as GARS1 [glycyl-tRNA synthetase (GlyRS)], which catalyzes the first step of protein synthesis), eventually many processes meet at the platform of intracellular trafficking. The gene discussed is GARS1; the disease is Charcot-Marie-Tooth disease.