Many types of CMT have shown to have cytoskeletal abnormalities (Brownlees et al., 2002), including mutations in PMP22 (CMT1A), MFN2 (CMT2A2), RAB7 (CMT2B), GARS1 (CMT2D), NEFL (CMT2E), HSPB1 (CMT2F), FIG4 (CMT4J), FGD4 (CMT4H), DNM2 (DI-CMT), and GJB1 (CMT1X). Here, MFN2 is linked to Charcot-Marie-Tooth disease.