Disruptions in mitochondria transport and location have been described in many sub-types of CMT including mutations in MFN2 (CMT2A2), RAB7 (CMT2B), GARS1 (CMT2D), NEFL (CMT2E), HSPB1 (CMT2F), and DYNC1H1 (CMT2O). The gene discussed is DYNC1H1; the disease is Charcot-Marie-Tooth disease.