Abnormalities in lysosomal degradation have been reported for mutations in PMP22, LITAF, RAB7, DYNC1H1, LRSAM1, MTMR2,13,5, NDRG1, and FIG4 causing CMT1A, 1C, 2B, 2O, 2P, 4B, 4D, and 4J, respectively. Here, FIG4 is linked to Charcot-Marie-Tooth disease type 1A.