Finally, when examining the association between alcohol trajectories and BC risk by pathological subtype, no significant differences (Wald test p value >0.05) were seen, except for the luminal HER2 negative subtype (ER+/PR+ and HER2−) (OR, alcohol trajectory 4 vs 1, 1.73; 95% CI 1.07, 2,82). The gene discussed is PGR; the disease is breast cancer.