The supporting data include 1) higher levels of cytoplasmic LC3/SQSTM1 complexes by in situ PLA, 2) the increased number of autophagic vesicles at the invasive front of human primary NSCLC tissue, and 3) the enhanced autophagic flux in the live invading cancer cells of the 3D organotypic cocultures. Here, SQSTM1 is linked to cancer.