We applied circRNA microarray assays, and first reported a novel OPLL-related circRNA, hsa_circ_0007292, which showed a higher expression level in OPLL tissues than normal tissues and participated in the pathogenesis and development of OPLL by targeting the miR-508-3p/SATB2 pathway. This evidence concerns the gene SATB2 and ossification of the posterior longitudinal ligament of the spine.