STX4 and cancer: Analysis results showed that the STX4 expression level was significantly related to several clinicopathological features of KIRC, including cancer status (P = 0.003), histological grade (P <  0.001), tumor size (T stage, P <  0.001), distant metastasis (M stage, P <  0.001), and American Joint Committee on Cancer (AJCC) stage (P <  0.001) (Table 1).