Moreover, increasing research has progressively unveiled the pivotal driver genes and pathways in DLBCL, such as TP53, MYC, BCL6, BCL2, MYD88, BCR pathway, NF-κB pathway, PI3K-AKT-mTOR pathway, and JAK-STAT pathway, etc., which help better understand the biological and pathological processes in DLBCL [8]. This evidence concerns the gene NFKB1 and diffuse large B-cell lymphoma.