PRKCA and rheumatic heart disease: The overall DNA methylation levels at these detected regions of PRKCA showed that PRKCA was hypomethylaed in RHD compared to health control (Fold change (FC) = 0.28, p = 0.021), where DNA methylation of promoter (FC = 0.23, p = 0.017) and the first exon (FC = 0.14, p = 0.009) of PRKCA was significantly lower in RHD compared to health control (Figure 1(b)).