Interestingly, in high‐risk glioma patients, the immune gene sets associated with immune promoting (TIL, CD8+ T cells, etc.)and immune‐suppressing (Treg, APC co‐inhibition, etc.)tumor immunity were both upregulated, but the prognosis was worse in high‐risk glioma patients as immunosuppression was positively correlated with risk score. This evidence concerns the gene CD8A and central nervous system cancer.