In the present study, the TLR4/CD14 expression levels in the pancreatitis-associated DHAV-1 and classical-type DHAV-1 infection groups were much higher than in uninfected ducklings, indicating that TLR4/CD14 may be involved in the host response to pancreatitis-associated DHAV-1 and classical-type DHAV-1 infection. This evidence concerns the gene TLR4 and pancreatitis.