Importantly, in another enzalutamide-resistant PCa cell line VCaP (VCaP ENZR, Fig. S1f), the protein and mRNA level of both AR-FL and its splice variant V7 (AR-V7) were significantly increased, together with upregulation of PSA, TMPRSS2 (Fig. S1g–i). The gene discussed is TMPRSS2; the disease is posterior cortical atrophy.