BMP2 and osteoporosis: Targeting the circ_0007059/miR-378/BMP2 axis is a potential method of osteoporosis treatment, and Liu et al. indicated that circ_0007059 (circBase ID: hsa_circ_ZNF720)was upregulated in patients with PMO and during osteoclastogenesis in hBMSCs, bound to miR-378 and downregulated BMP2 expression [22] (Fig. 3).