MAP1LC3A and cancer: Particularly, rSLURP-1 inhibited ERK-RSK autophagic axis, suppressed phosphorylation of JNK that drives LC3 cleavage, inhibited AKT, p70 s6 kinase, p38α MAP kinase, and Src family kinases (Src and Lyn) activity, which are all capable to activate autophagy in cancer cells.