In addition, HIF1α also plays key roles in promoting CSC phenotypes through ITGA6 forkhead box protein M1 (FOXM1), miR-215, and signal transducer and activator of transcription 3 (STAT3) activation in breast cancer, pancreatic cancer, colon cancer, and glioma, respectively [52–55]. This evidence concerns the gene STAT3 and malignant colon neoplasm.