Using transient transfections, we identified a minimal MICA promoter fragment spanning −270bp from the translation start site still responsive to NAE inhibition (Fig. 5 A), and regulated by the TFs IRF4, IKZF1, and IKZF3, previously identified as IMiDs and Bromodomain and Extra-terminal Domain inhibitors (BETi) “druggable” transcriptional repressors of this gene in MM cells [35, 60]. Here, MICA is linked to Miyoshi myopathy.