Another interesting study has reported that NF-κB transcriptionally actives CEBPA expression.62 However, in our study, although NF-κB is activated by LMP1, the STAT5/HDAC-mediated transcription repression is predominantly at the CEBPA promoter level, suggesting that histone acetylation is necessary for CEBPA activation in NPC. The gene discussed is STAT5A; the disease is nasopharyngeal carcinoma.