Yet, the precise activity of LMP1 in NPC development stays unclear as this membrane protein is usually expressed at low levels in a minority of NPC cells, possibly owing to proteasomal degradation.26 A recent immunohistochemistry (IHC) study showed that LMP1 was detected at high expression levels in 25.7% of NPC patients, which was associated with poor outcome.27 Hitherto, the role by which LMP1 may modulate the differentiation program remains to be clarified. Here, PDLIM7 is linked to nasopharyngeal carcinoma.