We have worked on the identification of molecular mechanisms underlying the cellular plasticity of NPC, breast cancer, and leukemia.6–10 Specifically, we demonstrated that EZH2-mediated repression of IKKα plays an essential role in maintaining the high plasticity phenotype of NPC cells.6 However, the early events and initiating mechanism responsible for acquiring the aberrant plasticity of NPC remains to be determined. The gene discussed is CHUK; the disease is nasopharyngeal carcinoma.