Moreover, in the case of cancers bearing mutations with loss-of-function or gain-of-function attributes downstream of p53 exon 9 (codon 331) (Table S3), NMD inhibition could restore p53 function by upregulating p53β/γ isoforms that lack the canonical C terminus and hence the mutations (Fig. S8, C and D). Here, TP53 is linked to cancer.