We detected 16 CRP × gut microbiome interaction with suggestive significance for anxiety GAD-7 score, like O_Bacteroidales (β = 0.010, P = 4.00 × 10–4), O_Selenomonadales (β = − 0.010, P = 1.20 × 10–3), O_Clostridiales (β = 0.009, P = 2.70 × 10–3) and G_Holdemanella (β = − 0.008, P = 4.20 × 10–3). Here, CRP is linked to Anxiety.