We also compared the above association analysis results, found 4 common CRP × gut microbiome interactions for both PHQ-9 score and GAD-7 score: G_Holdemanella (β = − 0.007, P = 1.43 × 10–2 for depression and β = − 0.008, P = 4.30 × 10–3 for anxiety), G_Desulfovibrio (β = 0.007, P = 2.64 × 10–2 for depression and β = 0.008, P = 6.30 × 10–3 for anxiety), F_Coriobacteriaceae (β = − 0.006, P = 4.57 × 10–2 for depression and β = − 0.005, P = 4.46 × 10–2 for anxiety) and G_Barnesiella (β = − 0.006, P = 3.16 × 10–2 for depression and β = − 0.006, P = 4.96 × 10–2 for anxiety). Here, CRP is linked to major depressive disorder.