For example, mammalian sirtuins (SIRTs), NAD-dependent histone deacetylase such as SIRT1 and SIRT3, were involved in oxidative stress and lipid metabolism regulation [33], and had been proposed as a reliable biomarker and/or therapeutic target for fatty liver disease [10, 19, 33, 35, 36]. The gene discussed is SIRT3; the disease is fatty liver disease.