The top 10 pathways of down-regulated DEGs with the greatest enrichment were cytokine-cytokine receptor interaction, protein digestion and absorption, extracellular matrix (ECM)-receptor interaction, hematopoietic cell lineage, influenza A, axon guidance, focal adhesion, inflammatory bowel disease (IBD), rheumatoid arthritis, and advanced glycation end-products/receptor for advanced glycation end-products (AGE-RAGE) signaling pathway in diabetic complications. The gene discussed is RENBP; the disease is rheumatoid arthritis.